{"id":97131,"date":"2025-03-13T23:13:27","date_gmt":"2025-03-13T21:13:27","guid":{"rendered":"https:\/\/www.lovendal.ro\/wp52\/?p=97131"},"modified":"2025-03-13T23:13:27","modified_gmt":"2025-03-13T21:13:27","slug":"oamenii-de-stiinta-au-intinerit-pielea-unei-femei-de-53-de-ani-aceasta-aratand-ca-cea-a-unei-femei-de-23-de-ani-intr-un-experiment-inovator","status":"publish","type":"post","link":"https:\/\/www.lovendal.ro\/wp52\/oamenii-de-stiinta-au-intinerit-pielea-unei-femei-de-53-de-ani-aceasta-aratand-ca-cea-a-unei-femei-de-23-de-ani-intr-un-experiment-inovator\/","title":{"rendered":"Oamenii de \u0219tiin\u021b\u0103 au \u00eentinerit pielea unei femei de 53 de ani, aceasta ar\u0103t\u00e2nd ca cea a unei femei de 23 de ani, \u00eentr-un experiment inovator"},"content":{"rendered":"

\"\"<\/a>\u00centr-o descoperire \u0219tiin\u021bific\u0103 remarcabil\u0103, cercet\u0103torii de la Institutul Babraham<\/strong> din Cambridge au inversat cu succes procesul de \u00eemb\u0103tr\u00e2nire a celulelor pielii, f\u0103c\u00e2ndu-le s\u0103 se comporte ca \u0219i cum ar apar\u021bine unei persoane cu 30 de ani mai t\u00e2n\u0103r\u0103. Aceast\u0103 dezvoltare a generat un entuziasm semnificativ \u00een comunitatea \u0219tiin\u021bific\u0103.<\/p>\n

Echipa \u0219i-a propus ini\u021bial s\u0103 genereze celule stem embrionare din celule adulte, o tehnic\u0103 lansat\u0103 pentru prima dat\u0103 de omul de \u0219tiin\u021b\u0103, c\u00e2\u0219tig\u0103tor al Premiului Nobel, Shinya Yamanaka<\/strong> \u00een 2006. Yamanaka, cercet\u0103tor la Universitatea din Kyoto, a demonstrat c\u0103 celulele adulte specializate pot fi reprogramate \u00een celule stem prin expunerea la patru molecule cheie. Aceste celule reprogramate, denumite celule stem pluripotente induse<\/strong> (iPS), au capacitatea de a se dezvolta \u00een orice tip de celul\u0103 din organism. Aceast\u0103 descoperire a revolu\u021bionat medicina regenerativ\u0103, permi\u021b\u00e2nd cercet\u0103torilor s\u0103 exploreze noi c\u0103i pentru repararea \u021besuturilor \u0219i poten\u021biale tratamente pentru bolile degenerative.<\/p>\n

Pornind de la aceast\u0103 baz\u0103, biologul molecular Wolf Reik<\/strong>, \u00eempreun\u0103 cu cercet\u0103torul Diljeet Gill<\/strong> \u0219i o echip\u0103 de la Institutul Babraham, au c\u0103utat s\u0103 perfec\u021bioneze procesul. \u00cen loc s\u0103 expun\u0103 celulele adulte ale pielii la moleculele de reprogramare timp de 50 de zile, a\u0219a cum f\u0103cuse Yamanaka, au redus timpul de expunere la doar 13 zile. Dup\u0103 acest tratament ini\u021bial, celulele au fost l\u0103sate s\u0103 creasc\u0103 natural \u00een condi\u021bii standard. S-a descoperit c\u0103, \u00een aceast\u0103 perioad\u0103, modific\u0103rile legate de v\u00e2rst\u0103 \u00een celulele pielii au fost \u0219terse efectiv. Celulele \u0219i-au pierdut momentan identitatea \u00eenainte de a-\u0219i rec\u0103p\u0103ta treptat func\u021bia de celule ale pielii. Pentru a evalua gradul de \u00eentinerire, cercet\u0103torii au examinat markerii biologici asocia\u021bi cu \u00eemb\u0103tr\u00e2nirea \u0219i produc\u021bia de colagen. Rezultatele au fost izbitoare – aceste celule tratate sem\u0103nau foarte mult cu cele ale unei tinere de 23 de ani, \u00een ciuda faptului c\u0103 provin de la o donatoare de 53 de ani.<\/p>\n

Reflect\u00e2nd la momentul \u00een care aceste constat\u0103ri au fost confirmate, Gill \u0219i-a amintit ne\u00eencrederea sa ini\u021bial\u0103. „\u00cemi amintesc ziua \u00een care am primit rezultatele. Unele dintre celule p\u0103reau cu 30 de ani mai tinere dec\u00e2t ar fi trebuit s\u0103 fie. A fost un moment incredibil de interesant”<\/em> – a spus el.<\/p>\n

Capacitatea de a restabili func\u021bia de \u00eentinerire a celulelor reprezint\u0103 o piatr\u0103 de hotar major\u0103 \u00een \u00een\u021belegerea modului \u00een care se produce \u00eemb\u0103tr\u00e2nirea la nivel biologic. Colagenul, o protein\u0103 esen\u021bial\u0103 care men\u021bine elasticitatea \u0219i structura pielii, se diminueaz\u0103 odat\u0103 cu v\u00e2rsta, duc\u00e2nd la apari\u021bia ridurilor \u0219i la reducerea fermit\u0103\u021bii pielii. Prin inversarea cu succes a acestui proces, studiul sugereaz\u0103 c\u0103 \u00eemb\u0103tr\u00e2nirea poate s\u0103 nu fie la fel de ireversibil\u0103 cum se credea anterior.<\/p>\n

Dup\u0103 anun\u021barea acestei descoperiri, reac\u021biile publicului, profesioni\u0219tilor medicali \u0219i industriei cosmetice au fost mixte. Mul\u021bi oameni \u0219i-au exprimat entuziasmul \u0219i speran\u021ba, v\u0103z\u00e2nd aceast\u0103 cercetare ca o poten\u021bial\u0103 solu\u021bie la preocup\u0103rile estetice.\u00a0Exper\u021bii \u00een dermatologie \u0219i medicin\u0103 regenerativ\u0103 au recunoscut importan\u021ba studiului, dar au cerut pruden\u021b\u0103.<\/p>\n

Conceptul de inversare a \u00eemb\u0103tr\u00e2nirii a fost un domeniu de interes \u00een ultimii ani, diverse studii explor\u00e2nd abord\u0103ri similare. \u00cen 2020, cercet\u0103torii de la Harvard Medical School<\/strong> au restabilit cu succes vederea la \u0219oarecii \u00een v\u00e2rst\u0103, prin reprogramarea celulelor oculare folosind factorii Yamanaka. Studiul lor, publicat \u00een „Nature”<\/em><\/strong>, a demonstrat c\u0103 celulele din retin\u0103 \u0219i-ar putea rec\u0103p\u0103ta func\u021bia de \u00eentinerire, suger\u00e2nd c\u0103 reprogramarea poate avea aplica\u021bii dincolo de celulele pielii.<\/p>\n

Aceste studii indic\u0103 faptul c\u0103 procesul de \u00eemb\u0103tr\u00e2nire nu este complet ireversibil, iar reprogramarea celular\u0103 \u021bintit\u0103 poate oferi \u00een cele din urm\u0103 noi metode pentru extinderea s\u0103n\u0103t\u0103\u021bii umane \u0219i a longevit\u0103\u021bii.<\/p>\n

Sursa<\/strong>: „Multi-omic rejuvenation of human cells by maturation phase transient reprogramming” \/ elifesciences.org<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u00centr-o descoperire \u0219tiin\u021bific\u0103 remarcabil\u0103, cercet\u0103torii de la Institutul Babraham din Cambridge au inversat cu succes procesul de \u00eemb\u0103tr\u00e2nire a celulelor pielii, f\u0103c\u00e2ndu-le s\u0103 se comporte ca \u0219i cum ar apar\u021bine unei persoane cu 30 de ani mai t\u00e2n\u0103r\u0103. Aceast\u0103 dezvoltare … <\/p>\n

Cititi mai multe<\/a><\/p>\n","protected":false},"author":1,"featured_media":97132,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[4905,145,463,7239,8505,11344,3990,1121,7964,12493,9794,3595,1953,309,8058,2162,16897,2250],"class_list":["post-97131","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina","tag-biolog","tag-boli","tag-cambridge","tag-celule","tag-celule-stem","tag-colagen","tag-dermatologie","tag-femeie","tag-imbatranire","tag-kyoto","tag-medicina","tag-molecule","tag-piele","tag-premiul-nobel","tag-proteina","tag-soarece","tag-tesuturi","tag-universitate","resize-featured-image"],"yoast_head":"\nOamenii de \u0219tiin\u021b\u0103 au \u00eentinerit pielea unei femei de 53 de ani, aceasta ar\u0103t\u00e2nd ca cea a unei femei de 23 de ani, \u00eentr-un experiment inovator - Secretele lui Lovendal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lovendal.ro\/wp52\/oamenii-de-stiinta-au-intinerit-pielea-unei-femei-de-53-de-ani-aceasta-aratand-ca-cea-a-unei-femei-de-23-de-ani-intr-un-experiment-inovator\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oamenii de \u0219tiin\u021b\u0103 au \u00eentinerit pielea unei femei de 53 de ani, aceasta ar\u0103t\u00e2nd ca cea a unei femei de 23 de ani, \u00eentr-un experiment inovator\" \/>\n<meta property=\"og:description\" content=\"\u00centr-o descoperire \u0219tiin\u021bific\u0103 remarcabil\u0103, cercet\u0103torii de la Institutul Babraham din Cambridge au inversat cu succes procesul de \u00eemb\u0103tr\u00e2nire a celulelor pielii, f\u0103c\u00e2ndu-le s\u0103 se comporte ca \u0219i cum ar apar\u021bine unei persoane cu 30 de ani mai t\u00e2n\u0103r\u0103. 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Aceast\u0103 dezvoltare ... 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