{"id":92944,"date":"2024-08-28T19:07:02","date_gmt":"2024-08-28T16:07:02","guid":{"rendered":"https:\/\/www.lovendal.ro\/wp52\/?p=92944"},"modified":"2024-08-28T19:07:02","modified_gmt":"2024-08-28T16:07:02","slug":"cercetatorii-au-descoperit-un-adn-ciudat-in-creierul-nostru-si-acesta-ar-putea-sa-ne-scurteze-viata","status":"publish","type":"post","link":"https:\/\/www.lovendal.ro\/wp52\/cercetatorii-au-descoperit-un-adn-ciudat-in-creierul-nostru-si-acesta-ar-putea-sa-ne-scurteze-viata\/","title":{"rendered":"Cercet\u0103torii au descoperit un ADN ciudat \u00een creierul nostru, \u0219i acesta ar putea s\u0103 ne scurteze via\u021ba"},"content":{"rendered":"
\"\"<\/a>
Imagine:<\/strong> pixabay.com<\/strong><\/a> (Commons Creative – free)<\/figcaption><\/figure>\n

Mitocondriile din celulele creierului \u00ee\u0219i introduc frecvent ADN-ul \u00een nucleu, ceea ce poate afecta durata de via\u021b\u0103, deoarece s-a descoperit c\u0103 cei cu mai multe inser\u021bii mor mai devreme. Stresul pare s\u0103 accelereze acest proces, suger\u00e2nd un nou mod \u00een care mitocondriile influen\u021beaz\u0103 s\u0103n\u0103tatea dincolo de produc\u021bia de energie. Potrivit unei noi cercet\u0103ri, aceste inser\u021bii de ADN mitocondrial ar putea fi legate de moartea timpurie.<\/p>\n

Ca descenden\u021bi direc\u021bi ai bacteriilor antice, mitocondriile au fost \u00eentotdeauna pu\u0163in intrigante. Acum, un nou studiu arat\u0103 c\u0103 mitocondriile sunt posibil chiar mai ciudate dec\u00e2t am crezut. Studiul a constatat c\u0103 mitocondriile din celulele creierului nostru \u00ee\u0219i arunc\u0103 frecvent ADN-ul \u00een nucleu, unde ADN-ul devine integrat \u00een cromozomii celulelor. \u0218i aceste inser\u021bii pot cauza r\u0103u: dintre cei aproape 1.200 de participan\u021bi la studiu, cei cu mai multe inser\u021bii de ADN mitocondrial \u00een celulele creierului au avut mai multe \u0219anse s\u0103 moar\u0103 mai devreme dec\u00e2t cei cu mai pu\u021bine inser\u021bii.<\/p>\n

„Obi\u0219nuiam s\u0103 credem c\u0103 transferul ADN-ului de la mitocondrii la genomul uman era un eveniment rar”<\/em>, a spus Martin Picard, biolog \u0219i profesor asociat de medicin\u0103 comportamental\u0103 la Columbia University, autorul principal al studiului. „Este uimitor c\u0103 acest lucru pare s\u0103 se \u00eent\u00e2mple de mai multe ori \u00een timpul vie\u021bii unei persoane. Am g\u0103sit multe dintre aceste inser\u021bii \u00een diferite regiuni ale creierului, dar nu \u00een celulele sanguine, explic\u00e2nd de ce zeci de studii anterioare care au analizat ADN-ul din s\u00e2nge au omis acest fenomen”.<\/em><\/p>\n

Mitocondriile tr\u0103iesc \u00een interiorul tuturor celulelor noastre, dar spre deosebire de alte organisme, mitocondriile au propriul lor ADN, o mic\u0103 caten\u0103 circular\u0103 cu aproximativ trei duzini de gene. ADN-ul mitocondrial este o r\u0103m\u0103\u0219i\u021b\u0103 din str\u0103mo\u0219ii no\u015ftri: bacterii str\u0103vechi care s-au instalat \u00een str\u0103mo\u0219ii no\u0219tri unicelulari cu aproximativ 1,5 miliarde de ani \u00een urm\u0103. \u00cen ultimele decenii, cercet\u0103torii au descoperit c\u0103 ADN-ul mitocondrial poate „s\u0103ri” ocazional. Mitocondriile elibereaz\u0103 segmente de ADN mitocondrial care pot c\u0103l\u0103tori prin porii nucleului \u0219i se pot integra \u00een cromozomii unei celule (unde inser\u021biile se numesc NUMT,<\/strong> pentru segmentele mitocondriale nucleare). Un nou studiu a constatat c\u0103 inser\u021bia ADN-ului mitocondrial nuclear – c\u00e2ndva era considerat\u0103 rar\u0103 – are loc \u00een creierul uman de mai multe ori \u00een timpul vie\u021bii unei persoane. Iar ADN-ul mitocondrial se comport\u0103 similar cu un virus.<\/p>\n

Ca urmare, to\u021bi ne plimb\u0103m cu sute de segmente de ADN mitocondrial vestigiale, \u00een mare parte benigne, \u00een cromozomii no\u0219tri pe care le-am mo\u0219tenit de la str\u0103mo\u0219ii no\u0219tri. Cercet\u0103torii au constatat c\u0103 inser\u021bia ADN-ului mitocondrial nuclear are loc \u00een creierul uman – mai ales \u00een cortexul prefrontal – \u0219i probabil de mai multe ori pe parcursul vie\u021bii unei persoane. De asemenea, au descoperit c\u0103 persoanele cu mai multe NUMT-uri \u00een cortexul lor prefrontal au murit mai devreme dec\u00e2t persoanele cu mai pu\u021bine NUMT-uri. Acest lucru sugereaz\u0103 c\u0103 NUMT-urile pot avea consecin\u021be func\u021bionale \u0219i poate influen\u021ba durata de via\u021b\u0103.<\/p>\n

Ce cauzeaz\u0103 NUMT-urile \u00een creier \u0219i de ce unele regiuni se acumuleaz\u0103 mai mult dec\u00e2t altele? Stresul face ca mitocondriile s\u0103 elibereze mai multe buc\u0103\u021bi din ADN-ul lor, iar aceste buc\u0103\u021bi pot „infecta” genomul nuclear.<\/p>\n

Sursa:<\/strong> studiul \u015ftiin\u0163ific „Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts” \/ plos.org<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Mitocondriile din celulele creierului \u00ee\u0219i introduc frecvent ADN-ul \u00een nucleu, ceea ce poate afecta durata de via\u021b\u0103, deoarece s-a descoperit c\u0103 cei cu mai multe inser\u021bii mor mai devreme. Stresul pare s\u0103 accelereze acest proces, suger\u00e2nd un nou mod \u00een … <\/p>\n

Cititi mai multe<\/a><\/p>\n","protected":false},"author":1,"featured_media":92945,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[415,9706,4905,7239,230,7030,3711,7199,9794,12355,1964,476,366,1150],"class_list":["post-92944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina","tag-adn","tag-bacterii","tag-biolog","tag-celule","tag-creier","tag-cromozomi","tag-gene","tag-genom","tag-medicina","tag-mitocondrii","tag-sange","tag-stres","tag-viata","tag-virus","resize-featured-image"],"yoast_head":"\nCercet\u0103torii au descoperit un ADN ciudat \u00een creierul nostru, \u0219i acesta ar putea s\u0103 ne scurteze via\u021ba - Secretele lui Lovendal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lovendal.ro\/wp52\/cercetatorii-au-descoperit-un-adn-ciudat-in-creierul-nostru-si-acesta-ar-putea-sa-ne-scurteze-viata\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cercet\u0103torii au descoperit un ADN ciudat \u00een creierul nostru, \u0219i acesta ar putea s\u0103 ne scurteze via\u021ba\" \/>\n<meta property=\"og:description\" content=\"Mitocondriile din celulele creierului \u00ee\u0219i introduc frecvent ADN-ul \u00een nucleu, ceea ce poate afecta durata de via\u021b\u0103, deoarece s-a descoperit c\u0103 cei cu mai multe inser\u021bii mor mai devreme. 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