{"id":87338,"date":"2023-08-11T16:16:42","date_gmt":"2023-08-11T13:16:42","guid":{"rendered":"https:\/\/www.lovendal.ro\/wp52\/?p=87338"},"modified":"2023-08-11T16:17:20","modified_gmt":"2023-08-11T13:17:20","slug":"enigmaticul-sistem-imunitar-al-nevertebratelor-neutralizeaza-bacteriile-toxice-printr-un-mecanism-uluitor","status":"publish","type":"post","link":"https:\/\/www.lovendal.ro\/wp52\/enigmaticul-sistem-imunitar-al-nevertebratelor-neutralizeaza-bacteriile-toxice-printr-un-mecanism-uluitor\/","title":{"rendered":"Misteriosul sistem imunitar al nevertebratelor neutralizeaz\u0103 bacteriile toxice printr-un mecanism uluitor"},"content":{"rendered":"

\"\"<\/a>Studiind vie\u021buitoarele m\u0103rilor, oamenii de \u0219tiin\u021b\u0103 au r\u0103mas uimi\u0163i de mecanismul imunitar al nevertebratelor oceanice. Bacteriile \u0219i nevertebratele coexist\u0103 de milioane de ani, de dinainte de evolu\u021bia vertebratelor. \u00centruc\u00e2t rolul primar al bacteriilor este acela de a descompune materia organic\u0103, nevertebratele primitive au dezvoltat un mecanism de imunitate care \u00eempiedic\u0103 bacteriile s\u0103 le invadeze \u021besuturile. Sistemul imunitar al omului \u0219i al vertebratelor au fost studiate \u00een detaliu, dar se cunoa\u0219te prea pu\u021bin despre mecanismul de ap\u0103rare al nevertebratelor.<\/p>\n

Se \u0219tie c\u0103 anticorpii din vertebrate servesc ca mecanism de ap\u0103rare esen\u021bial; c\u00e2nd formarea acestora se \u00eentrerupe, animalul devine vulnerabil. \u00cen cazul nevertebratelor, de\u0219i nu se produc anticorpi, ele sunt rezistente la bolile bacteriene. Pe ce se \u00eentemeiaz\u0103 aceast\u0103 imunitate? \u00cen studiile f\u0103cute, crabul Limulus polyphemus<\/em> numit \u0219i „crabul pantof de cal”, unul dintre cele mai vechi vie\u021buitoare de pe glob, a servit ca instrument primordial de cercetare. S-a dovedit astfel c\u0103 Limulus rezist\u0103 atacului bacterian prin formarea unui cheag de s\u00e2nge la locul infec\u021biei. S\u00e2ngele s\u0103u albastru neutralizeaz\u0103 compu\u0219ii toxici, secreta\u021bi de bacterii, prin agen\u021bi bactericizi poten\u021biali afla\u021bi \u00een s\u00e2ngele s\u0103u.<\/p>\n

Coagularea celulelor sanguine \u00een Limulus este produs\u0103, dup\u0103 toate probabilit\u0103\u021bile, de prezen\u021ba lipopolizaharidelor (LPS), o component\u0103 a pere\u021bilor celulari ai tuturor bacteriilor gram negative. Factorul de coagulare – care poate fi izolat din celulele sanguine – con\u021bine o enzim\u0103 activat\u0103 de LPS. Aceasta ac\u021bioneaz\u0103 asupra unei proteine de coagulare cu o greutate molecular\u0103 extrem de mic\u0103, rup\u00e2nd un lan\u021b polipeptidic rezultat din polimerizarea proteinei de coagulare. Reac\u021bia se nume\u015fte „Limulus amebocyte lysate test”<\/strong> (LAL<\/strong>). Prin \u00eendep\u0103rtarea unui inhibitor din LAL, s-au detectat 10^-11 LPS pe milimetru.<\/p>\n

Aceasta a f\u0103cut posibil\u0103 utilizarea testului \u00een domeniul farmaceutic \u0219i medical. \u00cen industria farmaceutic\u0103 el se folose\u0219te la detectarea contamin\u0103rilor cu LPS a medicamentelor injectabile, iar \u00een medicin\u0103 pentru a determina concentra\u021biile de LPS \u00een fluidele corporale (inim\u0103, splin\u0103, lichidul cefalorahidian). LPS (lipopolizaharidele componente ale pere\u021bilor celulari ai bacteriilor gram negative) sunt din punct de vedere biologic unele dintre cele mai active molecule cunoscute de om. Odat\u0103 intrate in fluxul sanguin ele pot provoca permeabilitatea capilar\u0103, coagularea intravascular\u0103, reac\u021bii pirogenice \u0219i moartea. Din cauza acestei toxicit\u0103\u021bi medicamentele injectabile trebuie testate cu grij\u0103 pentru a se determina dac\u0103 produsul nu dep\u0103\u0219e\u0219te cumva un nivel suportabil de LPS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Studiind vie\u021buitoarele m\u0103rilor, oamenii de \u0219tiin\u021b\u0103 au r\u0103mas uimi\u0163i de mecanismul imunitar al nevertebratelor oceanice. Bacteriile \u0219i nevertebratele coexist\u0103 de milioane de ani, de dinainte de evolu\u021bia vertebratelor. \u00centruc\u00e2t rolul primar al bacteriilor este acela de a descompune materia organic\u0103, … <\/p>\n

Cititi mai multe<\/a><\/p>\n","protected":false},"author":1,"featured_media":87339,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[16457,9706,4715,18451,4999,9794,16536,1964,6450,16537],"class_list":["post-87338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina","tag-anticorpi","tag-bacterii","tag-crab","tag-imunitate","tag-medicamente","tag-medicina","tag-nevertebrate","tag-sange","tag-tesut","tag-vertebrate","resize-featured-image"],"yoast_head":"\nMisteriosul sistem imunitar al nevertebratelor neutralizeaz\u0103 bacteriile toxice printr-un mecanism uluitor - Secretele lui Lovendal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lovendal.ro\/wp52\/enigmaticul-sistem-imunitar-al-nevertebratelor-neutralizeaza-bacteriile-toxice-printr-un-mecanism-uluitor\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Misteriosul sistem imunitar al nevertebratelor neutralizeaz\u0103 bacteriile toxice printr-un mecanism uluitor\" \/>\n<meta property=\"og:description\" content=\"Studiind vie\u021buitoarele m\u0103rilor, oamenii de \u0219tiin\u021b\u0103 au r\u0103mas uimi\u0163i de mecanismul imunitar al nevertebratelor oceanice. 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