{"id":102478,"date":"2026-05-19T20:24:56","date_gmt":"2026-05-19T17:24:56","guid":{"rendered":"https:\/\/www.lovendal.ro\/wp52\/?p=102478"},"modified":"2026-05-19T20:24:56","modified_gmt":"2026-05-19T17:24:56","slug":"vor-sa-ne-faca-sa-hibernam-cercetatorii-au-descoperit-ca-oamenii-au-deja-genele-hibernarii-in-adn-ul-lor","status":"publish","type":"post","link":"https:\/\/www.lovendal.ro\/wp52\/vor-sa-ne-faca-sa-hibernam-cercetatorii-au-descoperit-ca-oamenii-au-deja-genele-hibernarii-in-adn-ul-lor\/","title":{"rendered":"Vor s\u0103 ne fac\u0103 s\u0103 hibern\u0103m!?? Cercet\u0103torii au descoperit c\u0103 oamenii au deja genele hibern\u0103rii \u00een ADN-ul lor"},"content":{"rendered":"
\"\"<\/a>
Imagine:<\/strong> generata de Google Gemini<\/strong><\/figcaption><\/figure>\n

Animalele care hiberneaz\u0103 au o capacitate remarcabil\u0103 de a se recupera dup\u0103 schimb\u0103ri extreme de s\u0103n\u0103tate \u00een timpul hibern\u0103rii. \u00cens\u0103, dou\u0103 studii noi (conduse de Christopher Gregg<\/strong>, doctor \u00een filosofie \u015fi profesor de neurobiologie \u0219i genetic\u0103 uman\u0103 la Universitatea din Utah) arat\u0103 c\u0103 oamenii posed\u0103 acelea\u0219i instruc\u021biuni genetice pe care le folosesc animalele pentru a-\u0219i suprima \u0219i reporni metabolismul. Aceast\u0103 descoperire ar putea avea efecte profunde asupra dietelor, tratamentului diabetului de tip 2 \u0219i recuper\u0103rii dup\u0103 alte afec\u021biuni metabolice.<\/p>\n

Imagineaz\u0103-\u021bi c\u0103 ai putea petrece c\u00e2teva luni \u00een fiecare iarn\u0103 \u00een hibernare – e\u0219ti ghemuit \u00een pat, ritmul cardiac, temperatura corpului \u0219i activitatea cerebral\u0103 sunt drastic sc\u0103zute. Apoi, ie\u0219i la suprafa\u021b\u0103 prim\u0103vara, gata s\u0103 revii la rutina ta normal\u0103, recuper\u00e2ndu-te aproape imediat dup\u0103 aceste schimb\u0103ri de s\u0103n\u0103tate. Pentru animale precum ur\u0219ii, \u0219erpii, liliecii \u0219i altele, acest lucru este tipic. Pentru oameni, ar fi considerat un miracol medical. Totu\u0219i, conform a dou\u0103 studii, ambele publicate \u00een „Science”<\/em><\/strong>, superputerile de recuperare ale animalelor care hiberneaz\u0103 ar putea s\u0103 nu ne fie at\u00e2t de str\u0103ine pe c\u00e2t credem. \u00centr-adev\u0103r, acelea\u0219i instruc\u021biuni genetice pe care le au aceste animale ar putea fi ascunse \u00een propriul nostru ADN.<\/p>\n

Animalele care hiberneaz\u0103 trec prin schimb\u0103ri fiziologice dramatice. Temperatura corpului lor poate sc\u0103dea \u00een apropierea mediului \u00eenconjur\u0103tor, ritmul cardiac \u00eencetine\u0219te dramatic, metabolismul scade la doar c\u00e2teva procente din normal, iar activitatea cerebral\u0103 este redus\u0103 considerabil. La oameni, astfel de schimb\u0103ri ar provoca leziuni grave. La cei care hiberneaz\u0103, acestea sunt temporare \u0219i complet reversibile. Ceea ce le permite recuperarea nu este un organ de hibernare special, ci un program genetic extrem de coordonat.<\/p>\n

C\u00e2nd animalele care hiberneaz\u0103 se trezesc \u0219i \u00eencep s\u0103 m\u0103n\u00e2nce din nou, creierul lor – \u00een special o regiune numit\u0103 hipotalamus care controleaz\u0103 metabolismul – activeaz\u0103 rapid mii de gene. Aceast\u0103 faz\u0103 de realimentare \u0219i recuperare este de fapt momentul \u00een care au loc cele mai mari schimb\u0103ri moleculare. Aceste animale au comutatoare ADN reglatoare, numite elemente cis-reglatoare, care controleaz\u0103 modul \u00een care genele se activeaz\u0103 \u0219i se dezactiveaz\u0103 \u00een timpul postului \u0219i al recuper\u0103rii. De-a lungul a milioane de ani, animalele care hiberneaz\u0103 au dezvoltat modific\u0103ri subtile ale acestor comutatoare, multe dintre ele elimin\u00e2nd constr\u00e2ngerile care \u00een mod normal men\u021bin metabolismul stabil pe tot parcursul anului. Rezultatul este o flexibilitate extraordinar\u0103: pot suprima metabolismul \u00een siguran\u021b\u0103, apoi \u00eel pot reporni f\u0103r\u0103 a-l deteriora. Pe scurt, cei care hiberneaz\u0103 nu doar supravie\u021buiesc hibern\u0103rii – sunt programa\u021bi genetic pentru o recuperare \u00een siguran\u021b\u0103.<\/p>\n

\u00cen\u021belegerea modului \u00een care animalele care hiberneaz\u0103 se recupereaz\u0103 dup\u0103 schimb\u0103rile fiziologice men\u021bionate anterior ar putea duce \u00een cele din urm\u0103 la tratamente care ar ajuta la inversarea afec\u021biunilor precum diabetul de tip 2. Diabetul de tip 2 este, \u00een esen\u021b\u0103, o tulburare de inflexibilitate metabolic\u0103. Organismul se chinuie s\u0103 treac\u0103 de la starea de repaus alimentar la cea de hr\u0103nire. Semnalizarea insulinei devine nereglat\u0103, stocarea \u0219i utilizarea energiei devin dezechilibrate, iar \u021besuturile acumuleaz\u0103 daune.<\/p>\n

Animalele care hiberneaz\u0103 prezint\u0103 modelul opus. Ele devin inten\u021bionat rezistente la insulin\u0103 \u00eenainte de hibernare, suprim\u0103 metabolismul \u0219i apoi inverseaz\u0103 aceste schimb\u0103ri atunci c\u00e2nd se hr\u0103nesc din nou – f\u0103r\u0103 daune pe termen lung. Asta ne spune c\u0103 biologia flexibilit\u0103\u021bii metabolice exist\u0103 deja la mamifere.<\/p>\n

Pentru a ajunge la aceast\u0103 concluzie, Gregg \u0219i colegii s\u0103i au analizat genomurile mai multor specii care hiberneaz\u0103 \u0219i le-au comparat cu mamiferele care nu hiberneaz\u0103, inclusiv oamenii. C\u00e2nd cercet\u0103torii au descoperit aceste modific\u0103ri suprapuse, le-au urm\u0103rit p\u00e2n\u0103 la genele pe care acestea le regleaz\u0103 \u00een creierul \u0219oarecilor. Multe dintre aceste gene controleaz\u0103 r\u0103spunsurile metabolice la post \u0219i realimentare. Este important de men\u021bionat c\u0103 acelea\u0219i regiuni de ADN reglatoare se g\u0103sesc \u0219i \u00een creierul uman.<\/p>\n

Asta \u00eenseamn\u0103 c\u0103 oamenii au deja o mare parte din acelea\u0219i circuite genetice. Animalele care hiberneaz\u0103 nu au inventat gene noi. \u00cen schimb, au reglat fin comutatoarele de reglare existente. A\u015fadar, dac\u0103 oamenii de \u0219tiin\u021b\u0103 pot \u00een\u021belege \u0219i modula \u00een siguran\u021b\u0103 aceste comutatoare de reglare, ar putea fi capabili ca \u00een viitor s\u0103 \u00eembun\u0103t\u0103\u021beasc\u0103 toat\u0103 capacitatea organismului de a trece \u00eentre st\u0103ri metabolice, s\u0103 creasc\u0103 sensibilitatea la insulin\u0103 \u00een timpul recuper\u0103rii \u015fi s\u0103 reduc\u0103 daunele cauzate de stresul metabolic prelungit.<\/p>\n

Cercet\u0103torii spun c\u0103 scopul nu ar fi acela de a face oamenii s\u0103 hiberneze! S\u0103-i credem?<\/p>\n

Sursa:<\/strong> studiul \u015ftiin\u0163ific „Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus” \/ science.org<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Animalele care hiberneaz\u0103 au o capacitate remarcabil\u0103 de a se recupera dup\u0103 schimb\u0103ri extreme de s\u0103n\u0103tate \u00een timpul hibern\u0103rii. \u00cens\u0103, dou\u0103 studii noi (conduse de Christopher Gregg, doctor \u00een filosofie \u015fi profesor de neurobiologie \u0219i genetic\u0103 uman\u0103 la Universitatea din … <\/p>\n

Cititi mai multe<\/a><\/p>\n","protected":false},"author":1,"featured_media":102479,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[415,237,230,1502,3711,7420,6210,14217,7238,9794,10155,57,216,351,2250,15274,1971],"class_list":["post-102478","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicina","tag-adn","tag-animale","tag-creier","tag-filosofie","tag-gene","tag-hibernare","tag-hipotalamus","tag-lilieci","tag-mamifere","tag-medicina","tag-metabolism","tag-oameni","tag-serpi","tag-soareci","tag-universitate","tag-ursi","tag-utah","resize-featured-image"],"yoast_head":"\nVor s\u0103 ne fac\u0103 s\u0103 hibern\u0103m!?? 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